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Faculty and Staff - Dorothy J. Klimis-Zacas

School of Food and Agriculture
Food Science and Human Nutrition
Professor of Clinical Nutrition
5735 Hitchner Hall, Room 107
University of Maine
Orono, ME  04469-5736

Phone: (207)581-3124
Fax: (207) 581-1636
Email: dorothy.klimis.zacas@umit.maine.edu

Dr. Klimis-Zacas’ research web page

 

 Education
1982 Ph.D. Nutrition, The Pennsylvania State University, University Park, Pennsylvania

1978 M.S. Physiology, The Pennsylvania State University, University Park, Pennsylvania

1974 B.A. Biology and Honors, Beaver College, Glenside, Pennsylvania

Professional Experience | Courses Taught | Research Interests | Funded Projects | Publications | Professional Activities | Honors

Professional Experience 
Professor of Clinical Nutrition, University of Maine, Orono, Maine, 2003 to present

Cooperating Professor, Department of Nutrition and Dietetics, Harokopio University, Athens, Greece , 1996 to present

Associate Professor of Clinical Nutrition, University of Maine, Orono, Maine, 1994 to 2003

Fulbright Fellow, Athens School of Public Health, Athens, Greece, 1995 to 1996

Assistant Professor of Clinical Nutrition, University of Maine, Orono, Maine, 1988-1994

Visiting scientist at the Department of Physiological Chemistry, University of Cologne, Germany and the Department of Clinical Chemistry, University of Cologne Hospital, 1986-1987

Assistant Professor of Science, Husson College, Bangor, Maine, 1983- 1985

Instructor of Nutrition at the University of Maine, Orono, Maine, Summer 1981

Courses Taught
FSN 101 Introduction to Food and Nutrition -fall

FSN 420 Abnormal Nutrition (Medical Nutrition Therapy)- spring

FSN 510 Trace Minerals – spring, even years

FSN 584 Lipids in Health and Disease- spring, odd years

Research Interests

1. VASCULAR NUTRITION-NUTRITIONAL PHYSIOLOGY

• Functional foods and food bioactives on vasomotor function and aortic glycosaminoglycan structure and metabolism as related to Cardiovasular Disease and Obesity with the use of biosensors

2. NUTRITIONAL BIOCHEMISTRY-NUTRIGENOMICS

• Berry bioactives and their mechanism of action on inflammation and gene expression associated with the Metabolic Syndrome.

• The role of anthocyanins on cognitive performance and brain function and metabolism

• The bioavailability and metabolic fate of berry bioactives and their effect(s) on gut microbiota

3. CLINICAL NUTRITION

• Human interventions to study the role of food bioactives on Cardiovascular Disease, attenuation of oxidative stress, endothelial function, DNA protection and repair and gut microbiota

Funded Projects
Manganese, arterial functional properties and metabolism as related to cardiovascular disease

Manganese-proteoglycan-lipoprotein interactions and arterial wall functional properties

Whole wild blueberries and their effect on the biomechanical properties and metabolism of the rat aorta as related to hypertension

Wild blueberry-enriched diets and aortic glycosaminoglycan structure and metabolism as related to atherosclerosis

Selected Publications-last 5 years 

Vendrame S., Zhao A., Merrow T., Klimis-Zacas D. (2014). The effects of wild blueberry consumption on glucose metabolism in the obese Zucker rat, a model of metabolic syndrome. Journal of Medicinal Food, submitted for publication

Del Bo’ C., Porrini M., Fracassetti D., Campolo J., Klimis-Zacas D., Riso P. (2014). A single blueberry (Vaccinium corymbosum) portion prevents peripheral arterial dysfunction induced by acute cigarette smoke in young healthy volunteers. British Journal of Nutrition, submitted for publication

Taverniti V., Fracassetti D., Del Bo’ C., Lanti C., Minuzzo M., Klimis-Zacas D., Riso P., Guglielmetti S. (2014). Wild Blueberry anthocyanins exert immunomodulatory effects on human Caco-2 intestinal cells and U937 macrophages. Journal of Nutritional Biochemistry, submitted for publication

Vendrame S., Kristo A.S., Schuschke D.A., Klimis-Zacas D. (2014). Wild blueberry consumption affects aortic vascular function in the obese Zucker rat. Applied Physiology, Nutrition, and Metabolism, 39:255-61

Vendrame S., Daugherty A., Kristo A.S., Klimis-Zacas D. (2014). Wild blueberry-enriched diet (Vaccinium angustifolium) improves dyslipidemia and modulates gene expression related to lipid metabolism in obese Zucker rats.  British Journal of Nutrition, 111:194-200

Vendrame S., Daugherty A., Kristo A.S., Riso P., Klimis-Zacas D. (2013).Wild blueberry (Vaccinium angustifolium) consumption improves inflammatory status in the obese Zucker  rat model of the metabolic syndrome. Journal of Nutritional Biochemistry, 24:1508-12

Guglielmetti S., Fracassetti D., Taverniti V., Del Bo’ C., Vendrame S., Klimis-Zacas D., Arioli S., Riso P., Porrini M. (2013). Differential modulation of human intestinal Bifidobacterium populations after consumption of a wild blueberry (Vaccinium angustifolium) drink.  Journal of Agricultural and Food Chemistry, 61:8134-40

Lacombe A., Li R.W., Klimis-Zacas D., Kristo A.S., Tadepalli S., Krauss E., Young R., Wu V.C.H. (2013). Anthocyanin-rich lowbush wild blueberries have the potential to modify gut microbiota and enhance xenobiotic metabolism in the rat colon.
PloS One, 8:e67497

Kristo A.S, Kalea A.Z, Schuschke D.A, Klimis-Zacas D.J. (2013). Attenuation of alpha-adrenergic-induced vasoconstriction by dietary wild blueberries (Vaccinium angustifolium) is mediated by the NO-cGMP pathway in spontaneously hypertensive rats (SHRs). International Journal of Food Science and Nutrition, 64:979-87

Del Bo’ C., Porrini M., Fracassetti D., Campolo J., Klimis-Zacas D., Riso P. (2013). A single blueberry (Vaccinium corymbosum) portion prevents peripheral arterial dysfunction induced by acute cigarette smoke in young healthy volunteers. Pharmanutrition, 2:1-7

Fracassetti D., Del Bo’ C., Simonetti P., Gardana C., Klimis-Zacas D., Ciappellano S. (2013).  Effect of time and storage temperature on anthocyanin decay and antioxidant activity in wild blueberry (Vaccinium aungustifolium) powder. Journal of Agricultural and Food Chemistry, 61:2999−3005

Del Bo’ C., Riso P., Campolo J., Moller P., Loft S., Klimis-Zacas D., Brambilla A., Rizzolo A., Porrini M. (2013). A single portion of blueberry (Vaccinium corymbosum L) improves protection against DNA damage but not vascular function in healthy male volunteers. Nutrition Research, 33:220-7.

Riso P., Klimis-Zacas D., Del Bo’ C., Vendrame S., Martini D., Campolo J., De Maria R., Porrini M. (2013). The effect of wild blueberry (Vaccinium angustifolium) intake on markers of oxidative stress, inflammation and endothelial function in subjects with cardiovascular risk factors. European Journal of Nutrition, 52:949-61.

Lacombe A., Li R.W., Klimis-Zacas D., Kristo A.S., Tadepalli S., Krauss E., Young R., Wu V.C.H. (2012). Lowbush blueberries, Vaccinium angustifolium, modulate the functional potential of nutrient utilization and DNA maintenance mechanisms in the rat proximal colon microbiota. Functional Foods in Health and Disease, 2:228-241.

Papandreou M.A., Tsachaki M., Efthimiopoulos S., Klimis-Zacas D., Margarity M., Lamari F.N. (2012). Cell-Line Specific Protection by Berry Polyphenols Against Hydrogen Peroxide Challenge and Lack of Effect on Metabolism of Amyloid Precursor Protein. Phytotherapy Research, 26:956–963.

Del Bo’, C., Riso, P., Brambilla, A., Gardana, C., Rizzolo, A., Simonetti, P., Bertolo, G., Klimis-Zacas, D., Porrini, M. (2012). Blanching Improves Anthocyanin Absorption from Highbush Blueberry (Vaccinium corymbosum L.) Purée in Healthy Human Volunteers: A Pilot Study. Journal of Agricultural and Food Chemistry, 12:9298-304.

Kristo A.S, Malavaki C.J, Lamari F.N, Karamanos N.K, Klimis-Zacas D.J. (2012). Wild blueberry (V. angustifolium)-enriched diets alter aortic glycosaminoglycan profile in the spontaneously hypertensive rat. J Nutr Biochem. 2012, 23(8):961-5.

Klimis-Zacas D., Kristo A.S. Wild Blueberries (Vaccinium angustifolium): Modulators of Vascular Function, Structure, and Metabolism. In: Bhimanagouda SP, Guddadarangavvanahally KJ, Kotamballi NCM, Chidambara M, Navindra PS, editors. Emerging Trends in Dietary Components for Preventing and Combating Disease. ACS Publication Series, 2012, 151-166.

Del Bo’ C., Klimis-Zacas, D., Kristo, A., Riso, P., Porrini, M., Ciappellano, S. (2012). The temporal effect of a wild blueberry (Vaccinium angustifolium)-enriched diet on vasomotor tone in the Sprague-Dawley rat. Nutrition Metabolism and Cardiovascular Disease, 22:127-32.

Yiannakoulia M., Brusee S.E., Drichoutis A.C., Kalea A.Z., Yiannakouris N., Matalas A.L, Klimis-Zacas D. (2012). Food consumption patterns in Mediterranean adolescents:  Are there differences between overweight and normal weight adolescents?  Journal of Nutrition Education and Behavior, 44:233-9.

Vendrame  S., Guglielmetti S., Riso P., Arioli S., Klimis-Zacas D., Porrini M. (2011). Six-week consumption of a wild blueberry powder drink increases bifidobacteria in the human gut. Journal of Agricultural and Food Chemistry, 59:12815-20.

Del Bo’ C., Martini D., Vendrame S., Riso P., Ciappellano S., Klimis-Zacas D., Porrini M. (2010). Improvement of lymphocyte resistance against H2O2-induced DNA damage in Sprague-Dawley rats after eight weeks of a wild blueberry (Vaccinium angustifolium)-enriched diet. Mutation Research, 703:158-162.

Kalea A.Z, Clark K., Schuschke D.A., Kristo A.S., Klimis-Zacas D. (2010). Dietary enrichment with wild blueberries (Vaccinium angustifolium) affects the vasomotor pathways in young Spontaneously Hypertensive Rats (SHR). Journal of Nutritional Biochemistry, 21:14-22.

Kristo A., Kalea A.Z, Schuschke D., Klimis-Zacas D. (2010). A wild blueberry enriched diet (V. augustifolium) improves vascular tone in the adult Spontaneously Hypertensive Rat (SHR). Journal of Agricultural and Food Chemistry, 58:11600-5.

Del Bo’ C., Ciappellano S., Klimis-Zacas D., Martini D., Gardana C., Riso P., Porrini M. (2010). Anthocyanin Absorption, Metabolism, and Distribution from a Wild Blueberry-Enriched Diet (Vaccinium Angustifolium) Is Affected by Diet Duration. Journal of Agricultural and Food Chemistry, 58:2491-2497.

Kalea A.Z., Clark K., Schuschke D., Klimis-Zacas D. (2009). Vascular reactivity is affected by dietary consumption of wild blueberries in the Sprague-Dawley rat. Journal of Medicinal Food, 12:21-28.

Papandreou M.A., Dimakopoulou A., Cordopatis P., Klimis-Zacas D., Margarity M., Lamari F. (2009). Effect of a Polyphenol-rich Blueberry Extract on Cognitive Performance of Mice on Brain Antioxidant Markers and Acetylcholinesterase Activity. Behavioural Brain Research,198:352-358.

Books Edited
D. Klimis-Zacas and I. Wolinsky. Nutritional Concerns of Women, CRC Press Inc., Boca Raton, Fl., 2003. (2nd edition)

D. Klimis-Zacas. Annual Editions: Nutrition 2001/02, McGraw-Hill/Dushkin (2001)

D. Klimis-Zacas, Annual Editions: Nutrition 2002/2003, McGraw-Hill/Dushkin (2002)

D. Klimis-Zacas, Annual Editions: Nutrition 2003/2004, McGraw-Hill/Dushkin (2003)

D. Klimis-Zacas, Annual Editions: Nutrition 2004/2005, McGraw-Hill/Dushkin (2004)

D. Klimis-Zacas, Annual Editions:  Nutrition 2005/2006, McGraw-Hill/Dushkin (2005)

D. Klimis-Zacas, Annual Editions:  Nutrition 2006/2007, McGraw-Hill/Dushkin (2006)

D. klimis-Zacas, Annual Editions:  Nutrition2007/2008, McGraw-Hill/Dushkin (2007)

Professional Activities and/or Services
Editorial Board for CRC Press Series in Modern Nutrition

Editor in Chief for Annual Editions: Nutrition, McGraw-Hill/Dushkin

Member, American Dietetic Association, R.D. eligible

Member, American Society for Nutritional Sciences

Member, Atherosclerosis Society (International)

Member, Maine Nutrition Council

Member, Maine Dietetic Association

Member, Hellenic Dietetic Association

Professor Klimis-Zacas is a member of the Planning Committee for the Tri-Society International Conference for Trace Element Research in Humans (ISTERH), Nordic Trace Element Society (NTES)
and the Hellenic Trace Element Society (HTES) on “Trace Elements in Diet, Nutrition and Health: Essentiality and Toxicity” to be held October 21-26, 2007 in the beautiful island of Crete, Greece.  She
Chairs the session on “Trace elements: Modulators of Arterial function and Metabolism”.
She is also member of the Fund raising committee of the Conference.

Professor Klimis-Zacas attended the 10th annual Conference of the Wild Blueberry Health Research group in Bar Harbor, Maine, August 15-19, 2007 where she presented her research findings.
She was interviewed on Channel 5 and 7, Bangor, Bangor Daily News, and CBC Canada on her research on wild blueberries and their effects on vasorelaxation and cardiovascular disease as well on the contributions of the FSN faculty to wild blueberry research and Maine economy.

Honors

Professor Dorothy Klimis-Zacas has been named a Senior Fulbright Specialist for 2007-2012. The award, which promotes collaborations with non-U.S. academic institutions world-wide, requires rigorous application and selection process. It enables the specialist to travel to a foreign country from two to six weeks to collaborate on curriculum and faculty development, institutional planning and other activities (2007-2012)

Fulbright Fellow, School of Public Health, Athens, Greece (1995)

Recipient of Helena Rubinstein Foundation Chemistry Scholarship

Who’s Who in the East

American Men and Women of Science

Sigma Xi (Research Honor Society)


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